Actively Recruiting
Microbiome and Sarcopenia in Patients With Liver Cirrhosis
Led by Medical University of Graz · Updated on 2024-10-09
120
Participants Needed
1
Research Sites
503 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity of malnutrition correlates with progression of liver disease and leads to sarcopenia in 30-70% of cirrhotic patients. Malnutrition and sarcopenia are associated with an increased risk of complications and mortality. In cirrhosis the gut microbiome is altered leading to increased gut permeability, bacterial translocation and inflammation. Since the microbiome is involved in nutrient uptake and metabolism, it is hypothesized that microbiome alterations contribute to sarcopenia. A prospective controlled cohort study to investigate the interrelation of microbiome changes and sarcopenia in cirrhosis will be conducted. Furthermore the effect of nutritional interventions on the microbiome in cirrhosis will be studied. From this study information on how the gut microbiome composition and sarcopenia are associated in cirrhosis and if modulation of the gut microbiome by nutritional interventions is feasible will be collected.
CONDITIONS
Official Title
Microbiome and Sarcopenia in Patients With Liver Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patients for any reason with clinical, radiological, or histological diagnosis of cirrhosis
- Age over 18 years
- Able to provide informed consent
- CT or MRI scan performed within 14 days before or after the baseline study visit
You will not qualify if you...
- Hepatic encephalopathy above grade 2 or other cognitive disorders preventing informed consent
- Advanced hepatocellular carcinoma
- Any condition or circumstance that may affect the patient's ability to participate in the study, as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical University Graz
Graz, Austria
Actively Recruiting
Research Team
V
Vanessa Stadlbauer-Köllner, AssocProf Dr
CONTACT
J
Julia Haberl, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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