Actively Recruiting
Microbiota Transplantation in Solid Organ Transplantation
Led by The Second Hospital of Nanjing Medical University · Updated on 2024-12-12
50
Participants Needed
1
Research Sites
573 weeks
Total Duration
On this page
Sponsors
T
The Second Hospital of Nanjing Medical University
Lead Sponsor
T
The Chinese fmtBank
Collaborating Sponsor
AI-Summary
What this Trial Is About
Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life. Posttransplant complications such as gastrointestinal symptoms, infection, and graft rejection increase risk with graft failure and death. However, the treatment of abovementioned complications remains unsatisfactory. Gut dysbiosis has been reported in patients with SOT, especially in patients with posttransplant complications. Recipients are more susceptible to gut dysbiosis as long-term use of immunosuppressants, antibiotics and corticosteroids. Restoring gut microbiome may be a promising therapy for posttransplant complications. Washed microbiota transplantation (WMT) is a newly improved methodology of fecal microbiota transplantation based on automatic facilities, washing process and a new delivery routine. In this study, investigators aimed to evaluate the efficacy and safety of WMT for postoperative complications in SOT.
CONDITIONS
Official Title
Microbiota Transplantation in Solid Organ Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Solid organ transplantation recipients
- Experiencing gastrointestinal symptoms such as diarrhea, constipation, or abdominal pain, or infections like Clostridium difficile after transplantation
- Willing to undergo washed microbiota transplantation and provide written informed consent
You will not qualify if you...
- History of gastrointestinal diseases or homologous pathogen infection before transplant
- Pregnant or breastfeeding females
- Expected survival less than 1 month
- Unable to understand the study purpose, communicate with investigators, or comply with study procedures
- Unable to complete follow-up for at least 1 month after washed microbiota transplantation
- Other conditions judged by investigators as unsuitable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
F
Faming Zhang, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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