Actively Recruiting
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Tissues From Egyptian Male Patients and Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder Cancer.
Led by Theodor Bilharz Research Institute · Updated on 2024-03-01
38
Participants Needed
2
Research Sites
197 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Microbes inhabiting the urinary tract that are playing an important role in maintenance of health and the development of diseases and bladder cancer. There is correlation between initiation of bladder cancer and microbes. Urine and bladder tissues from healthy individuals and patients with bladder cancer were analyzed using 16S rRNA sequencing, results show abundant phylum. Next-generation sequencing technologies will be applied with whole genomic and 16S ribosomal RNA gene sequencing for microbiota profiling in urine and bladder tissue of male healthy individuals and patients with bladder cancer. Results will lead to prevention, diagnosis, and new treatment strategies for bladder cancer.
CONDITIONS
Official Title
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Tissues From Egyptian Male Patients and Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult men above 18 years old
- Diagnosed with bladder cancer confirmed by imaging and urine cytology
- Bladder cancer confirmed by diagnostic cystoscopy, previous pathology, or biopsy examination
You will not qualify if you...
- Previous radiotherapy to the bladder or adjacent organs
- Previous intravesical immunotherapy with bacillus Calmette-Gu�e9rin (BCG) or intravesical chemotherapy
- Previous neoadjuvant chemotherapy
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Theodor Bilharz Research Institute
Cairo, Giza Governorate, Egypt, 12411
Not Yet Recruiting
2
Theodor Bilharz Research Institute
Cairo, Egypt, 12411
Actively Recruiting
Research Team
M
Mohamed M Wishahi, MD
CONTACT
M
Mohamed Wishahi, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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