Study of Radiotherapy Effects on Tumor Microenvironment in Cervical and Pancreatic Cancer Patients Collecting Biospecimens and Imaging During and After Treatment

What this Trial Is About

Researchers are conducting a prospective longitudinal study to understand the effects of chemoradiotherapy on the tumor environment in patients with locally advanced cervical and pancreatic cancers. The study aims to collect detailed biological samples and treatment-related data before, during, and after definitive chemoradiotherapy to better capture changes within the tumor microenvironment. Participants will provide blood and tumor samples at multiple time points throughout the study, including before treatment, during treatment, and at recurrence if applicable. Standard imaging as part of routine care will be performed alongside specialized diffusion basis spectrum imaging DBSI MRI scans, taken at specific intervals such as initial staging and after treatment completion. These procedures aim to gather comprehensive data on tumor changes related to therapy. During the study, participants will undergo regular assessments involving biospecimen collection, imaging scans, and clinical data gathering. Researchers will monitor changes in the tumor microenvironment from the start of follow-up through an estimated 5-year period. Participants will be followed closely to evaluate tumor biology and treatment effects while safety and clinical status are observed throughout their involvement.

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial