MicroEnvironment Tumor Effects of Radiotherapy Comprehensive Radiobiology Assessment TRial (METEOR-CRATR) for Locally Advanced Cervical and Pancreatic Cancer

What this Trial Is About

Researchers are conducting a prospective longitudinal study to understand the effects of chemoradiotherapy on the tumor environment in patients with locally advanced cervical and pancreatic cancers. The study aims to collect detailed treatment-related data, including imaging and clinical results, along with biospecimens such as biopsies and blood samples taken before, during, and after treatment. The study involves collecting tumor biopsies and blood samples at various time points depending on the cancer type. For cervical cancer, biopsies are collected before radiation, one week and three weeks after starting radiation, and at recurrence. For pancreatic cancer, biopsies are taken before stereotactic body radiotherapy (SBRT), 12 weeks after radiotherapy, and at recurrence. Blood samples and advanced MRI imaging are also scheduled at specific intervals throughout treatment and follow-up. Participants will undergo imaging assessments using diffusion basis spectrum imaging MRI at initial staging and during follow-up visits. The study measures changes in the tumor microenvironment over an estimated five-year follow-up period. Throughout the study, researchers collect clinical data, monitor treatment effects, and evaluate tumor biology to better understand responses to radiotherapy.

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial