Clinical Efficacy of Arthroscopic Microfracture Combined With Local Injection of Platelet Rich Plasma Gel in Treatment of Osteochondral Lesion of the Talus: A Randomized Control Trial

What this Trial Is About

Researchers are evaluating whether adding a local injection of platelet rich plasma (PRP) gel to arthroscopic microfracture surgery improves treatment for osteochondral lesions of the talus (OLT), a condition causing chronic ankle pain. This randomized, double-blind trial compares combined PRP gel injection with isolated microfracture surgery. The study aims to see if the combined approach enhances ankle function based on the American Orthopedic Foot and Ankle Society (AOFAS) Score and improves cartilage healing as seen on MRI scans. Participants receive either isolated arthroscopic microfracture surgery or the same surgery combined with PRP gel injection prepared from the participant's own blood. During surgery, damaged cartilage and bone are cleaned, and microfracture channels are created in the lesion. For the experimental group, PRP gel is made by processing the participant's blood and injected directly into the injured area under arthroscopic guidance. The study includes follow-ups at 3, 6, 12, and 24 months to assess outcomes. Throughout the trial, participants undergo clinical assessments of ankle function using various scales including AOFAS, Foot and Ankle Outcome Score, and Visual Analogue Scale at multiple time points before and after surgery. MRI scans are performed preoperatively and at 6, 12, and 24 months post-surgery to monitor cartilage repair. Researchers also track patient satisfaction, return-to-sport rates, and any complications up to 24 months. The total participation lasts about two years with regular clinical and imaging evaluations.

Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus