Actively Recruiting
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-03-16
80
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions. Finger movement can be restored by surgery (removing the fibrosis tissue), but recurrence is a major problem and this is difficult to treat. Through microfasciectomy, the presence of small nerve bundles (micronerves) were observed. These nerves are possibly related to the hand fascia, which is the origin of Dupuytren disease. These micornerves and their dissection could play a role in the recurrence of DD. This study will investigate the role of these micronerves in DD, the impact of its dissection on formation of neuromas and on recurrence. Also, the presence of nerve growth factor (NGF) will be evaluated. The purpose is to provide information on potential neuro-induced fibrosis.
CONDITIONS
Official Title
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent prior to the first assessment
- Age 18 years or older
- Diagnosed with primary or recurrent Dupuytren disease
- Eligible for microfasciectomy surgery
You will not qualify if you...
- Under 18 years of age
- Participation in an interventional trial with an investigational medicinal product
- Cognitive impairments, severe rheumatic disease, or neurological disorders causing finger flexion deformities
AI-Screening
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Trial Site Locations
Total: 1 location
1
Universitaire Ziekenhuizen KU Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
Research Team
I
Ilse Degreef, Prof. Dr.
CONTACT
A
Anna Tarasiuk
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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