Micronutrient and Additive Modifications May Optimize Diet To Health for Moderately Active Ulcerative Colitis

What this Trial Is About

Researchers are evaluating the effects of dietary changes on patients with moderately active ulcerative colitis. This prospective clinical trial compares a normal healthy diet to a diet that eliminates specific emulsifying agents, particularly carrageenan, CMC, and polysorbates, which are part of the E 400 additive group. The goal is to see if removing these additives can improve disease activity and the gut microbiota. Participants are randomly assigned to one of two groups: one group receives standard dietary advice for ulcerative colitis, while the other group receives advice to eliminate E400 additives from their diet. Diets are recorded at the beginning and after one month using a food diary and a food frequency questionnaire focused on E400 intake. Clinical characteristics, disease activity markers like diarrhea frequency, blood in stools, abdominal pain, CRP, calprotectin, and microbiota samples are collected and analyzed. During the study, participants will have their diets and clinical status assessed at the start and after one month. Researchers will measure outcomes including calprotectin levels and microbiota diversity to evaluate disease activity and gut health. The study includes monitoring of clinical symptoms and microbiota composition using advanced sequencing methods. Participation involves diet recording and clinical assessments over a one-month period to track changes and safety.

Micronutrient and Additive Modifications May Optimize Diet To Health