Actively Recruiting
Microplastic Exposure From Clear Aligner Wear (MPE)
Led by University of North Carolina, Chapel Hill · Updated on 2025-09-19
150
Participants Needed
1
Research Sites
516 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An observational longitudinal study measuring microplastic exposure and physiologic uptake in orthodontic patients receiving clear aligner treatment.
CONDITIONS
Official Title
Microplastic Exposure From Clear Aligner Wear (MPE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals of any sex, gender, race, and ethnicity aged 10 to 75 years
- Receiving comprehensive Phase II orthodontic treatment with clear aligner therapy
- Stable physical health classified as ASA I or II as determined by study staff
- Able to understand and follow study requirements including attending scheduled visits
- Provided patient and parental consent (and assent for minors) to participate in the study
You will not qualify if you...
- Receiving orthodontic treatment with fixed appliances
- Receiving hybrid treatment with fixed appliances and aligners
- Receiving Phase I orthodontic treatment with fixed appliances
- History of severe dry mouth, severe periodontal disease with active bleeding gums, significant oral abrasions, ulcers, or growths
- Current alcohol abuse or recreational drug abuse
- Other severe acute or chronic medical or psychiatric conditions or lab abnormalities increasing study risk
- Drinking, eating, or brushing teeth within 1 hour before study visit
- Removing aligners within 1 hour before study visit
- Developmental or cognitive disability preventing self-consent or study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
L
Laura A Jacox, DMD, PhD, MS
CONTACT
S
S.T. Phillips, BSDH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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