Actively Recruiting
Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)
Led by Azienda Ospedaliera "Sant'Andrea" · Updated on 2025-05-11
130
Participants Needed
10
Research Sites
140 weeks
Total Duration
On this page
Sponsors
A
Azienda Ospedaliera "Sant'Andrea"
Lead Sponsor
U
University of Campania Luigi Vanvitelli
Collaborating Sponsor
AI-Summary
What this Trial Is About
Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.
CONDITIONS
Official Title
Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- STEMI undergoing urgent invasive coronary angiography
- Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1)
- Clinical indication to thromboaspiration
- Able to give informed consent
You will not qualify if you...
- Contraindications to percutaneous coronary intervention
- Hemodynamic instability or cardiogenic shock
- End-stage chronic kidney disease
- Life expectancy < 1 year due to non-cardiac pathology
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Sant'Andrea University Hospital
Roma, Rome, Italy, 00189
Actively Recruiting
2
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli
Caserta, Italy
Active, Not Recruiting
3
Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.
Caserta, Italy
Not Yet Recruiting
4
Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.
Catania, Italy
Not Yet Recruiting
5
Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy
Ferrara, Italy
Not Yet Recruiting
6
Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.
Forlì, Italy
Not Yet Recruiting
7
Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy.
Milan, Italy
Not Yet Recruiting
8
Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.
Naples, Italy
Active, Not Recruiting
9
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy.
Turin, Italy
Not Yet Recruiting
10
Azienda Ospedaliera Integrata Verona, Italy
Verona, Italy
Actively Recruiting
Research Team
E
Emanuele Barbato, MD, PhD
CONTACT
C
Clinical Research Unit Cardiology Dept. Sant'Andrea University Hospital
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here