Investigation of Microplastics and Nanoplastics in Adults with Chronic Coronary Syndromes Undergoing Coronary CT and Invasive Angiography

What this Trial Is About

Researchers are investigating the presence and impact of microplastics and nanoplastics MNPs in adults with chronic coronary syndromes CCS undergoing coronary CT angiography CCTA and invasive coronary angiography. This observational study aims to analyze these particles in coronary blood and explore their relationship with coronary artery disease features, including plaque characteristics and vessel ischemia. Patients are followed up clinically at 1 and 3 years according to standard care. Participants undergo routine coronary CT angiography to assess suspected or known CCS and then invasive coronary angiography when clinically indicated. During invasive procedures, coronary blood samples are collected for central laboratory analysis of MNPs using specialized techniques such as pyrolysis-gas chromatography-mass spectrometry and laser direct infrared spectroscopy. The CCTA images are centrally evaluated to quantify and characterize coronary plaques. Patients are grouped based on the presence or absence of MNPs in coronary blood. Throughout the study, patients receive standard clinical management without changes to their care. Data collected include coronary blood MNP burden, plaque features from CCTA, and clinical outcomes such as major adverse cardiovascular events and mortality over 1- and 3-year follow-ups. The study monitors correlations between MNP levels and various imaging and clinical parameters to better understand their role in CCS progression and outcomes.

Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes