Actively Recruiting
MicroRNA Regulation of Chronic Inflammation During Aging
Led by University of Utah · Updated on 2025-12-05
40
Participants Needed
1
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation. The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.
CONDITIONS
Official Title
MicroRNA Regulation of Chronic Inflammation During Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 35 years or 65 years and older
- Body mass index (BMI) less than 30 kg/m2
- Ability to provide informed consent
- For older participants: Clinical Frailty Scale score less than 3 and Mini-Cog score greater than 3
- Good general health, able to walk, and living independently
You will not qualify if you...
- History of cardiovascular diseases such as congestive heart failure, coronary artery disease, heart attack, or stroke
- Endocrine or metabolic diseases like untreated hypo/hyperthyroidism or diabetes (treated hypo/hyperthyroidism for at least 6 months allowed)
- Kidney disease stage greater than 4
- History of vascular disease
- Uncontrolled high blood pressure (systolic over 150 or diastolic over 100)
- Cancer or history of cancer treated less than 1 year ago (except basal cell carcinoma)
- Use of systemic corticosteroids for 2 weeks or more within 4 weeks before study or during study
- Use of anti-inflammatory medications for 2 weeks or more within 4 weeks before study
- Chronic inflammatory conditions (e.g., rheumatoid arthritis, Crohn's disease, fibromyalgia, lupus, colitis), HIV, hepatitis B or C
- History of stroke with motor disability
- Recent gastrointestinal bleeding within last 12 months
- Liver disease or liver enzyme levels twice the normal limit
- Respiratory disease such as acute infections or chronic lung disease
- Current smokers or current tobacco users
- Current pregnancy confirmed by positive test
- Staff members reporting directly to principal investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
The University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
Research Team
M
Micah Drummond, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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