Actively Recruiting
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Led by University of Pennsylvania · Updated on 2025-07-18
500
Participants Needed
3
Research Sites
212 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.
CONDITIONS
Official Title
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- For cases: moderate to severe obstructive sleep apnea defined as apnea-hypopnea index (AHI) of 15 or more events per hour
- Willingness to use Positive Airway Pressure (PAP) therapy (for cases)
- For controls: no obstructive sleep apnea defined as AHI less than 5 events per hour
You will not qualify if you...
- Current use of PAP or other treatments for obstructive sleep apnea (cases)
- Current home oxygen therapy
- Changes to blood pressure medications within the past 3 months (for those taking these medications, cases only)
- Presence of Cheyne-Stokes Respiration in sleep study
- Predominantly central sleep apnea with AHI 15 or more events per hour and more than 50% central events
- Pregnancy
- History of chronic kidney disease stage 5 requiring dialysis or renal transplant
- Organ transplantation
- Self-reported sleep duration less than 5 hours per night on weeknights
- Current night shift work
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600
Columbus, Ohio, United States, 43221
Actively Recruiting
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
3
University of Iceland
Reykjavik, Iceland
Actively Recruiting
Research Team
C
Colleen M Walsh, MS
CONTACT
K
Kristie C Nguyen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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