Actively Recruiting
Microvascular Cardiac Allograft Vasculopathy Trial
Led by German Heart Institute · Updated on 2024-08-12
50
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
G
German Heart Institute
Lead Sponsor
D
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the mCAV study is a comprehensive characterization of the genetic, morphological and functional phenotype of isolated microvascular graft vasculopathy (mCAV) after orthotopic heart transplantation (OHT). The utilized methods include dynamic echocardiography, magnetic resonance imaging, invasive microvascular resistance measurements, histology, cellular calcium-signaling and magnetocardiography as well as molecular genetic expression analysis (miRNA based).
CONDITIONS
Official Title
Microvascular Cardiac Allograft Vasculopathy Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to consent
- Written consent provided after explanation and consideration
- Heart transplant recipient
- Indication for routine invasive diagnostics or symptoms
- Exercise tolerance in daily life (cycling, climbing at least 2 floors at moderate speed without symptoms)
You will not qualify if you...
- Addiction or diseases preventing understanding of the study
- Inability to provide or understand written consent due to language barriers
- Pregnant or breastfeeding women
- Severe comorbidities affecting miRNA profile: diabetes mellitus, malignancy, end-stage renal disease with renal replacement therapy
- Contraindications to stress test including cardiac decompensation, angina, dyspnea, hyperthyroidism, GFR <30 ml/min, peripheral arterial disease, pheochromocytoma, angle-closure glaucoma, prostate adenoma, paroxysmal tachycardia, atrial fibrillation
- Evidence of acute rejection or local wall motion disturbances on resting echocardiography
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
DHZC Deutsches Herzzentrum der Charité
Berlin, Germany, 13353
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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