Actively Recruiting
Middle Cerebral Artery Aneurysm Trial
Led by University of Alberta · Updated on 2026-03-13
400
Participants Needed
1
Research Sites
815 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option. Most MCA aneurysms are accessible, proximal control can readily be secured in case of rupture, and clip application can typically proceed without requiring the dissection of perforating arteries. In comparison, certain anatomic features of MCA aneurysms such as a wide neck, often including a branch artery origin, frequently render endovascular management more difficult. New endovascular devices were and continue to be introduced to address these anatomic difficulties, including stents, flow diverters, and intra-saccular flow disruptors (ISFDs) such as the WEB. Thus, while most aneurysms are increasingly treated with endovascular methods, many MCA aneurysm patients are still managed surgically, but convincing evidence of which management paradigm is best is lacking.
CONDITIONS
Official Title
Middle Cerebral Artery Aneurysm Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients at least 18 years of age
- At least one documented, intradural, intracranial aneurysm anywhere on the course of the MCA vessel, ruptured or unruptured
- Untreated ruptured aneurysm suspected to have occurred more than 30 days prior to inclusion considered unruptured
- In the case of subarachnoid hemorrhage (SAH), World Federation of Neurosurgical Societies (WFNS) grade 4 or less
- Patient and aneurysm considered appropriate for either surgical or endovascular treatment by the treating team
You will not qualify if you...
- Absolute contraindications to administration of any type of contrast material
- Patients with arteriovenous malformation (AVM)-associated aneurysms
- Patients or caregivers unable to provide consent
- Poor grade (WFNS 5) ruptured aneurysms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alberta
Edmonton, Canada
Actively Recruiting
Research Team
S
Sudeshna Bhattacharyna
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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