Actively Recruiting
Outcomes of Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma; Middle Meningeal Artery Embolization for Chronic Subdural Hematoma (MESH)
Led by Montefiore Medical Center · Updated on 2026-01-07
5000
Participants Needed
19
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Montefiore Medical Center
Lead Sponsor
G
Geisinger Clinic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic subdural hematoma (cSDH) is a common neurosurgical condition characterized by blood buildup in the subarachnoid space, mainly affecting older adults and linked to serious health risks. Researchers are exploring the outcomes of treating cSDH with middle meningeal artery embolization (MMAE) to assess its clinical effectiveness, recurrence rates, and safety. This multi-center retrospective cohort study aims to evaluate whether MMAE shows a favorable safety profile with few treatment-related complications. The study observes adult patients who have undergone endovascular embolization of the middle meningeal artery using approved embolization materials such as PVA particles, Onyx, nBCA glue, dimethyl sulfoxide, microcoils, or combinations thereof. Participants have received this minimally invasive treatment, which is being assessed for its role in managing cSDH. No experimental interventions or control groups are involved as this is an observational study. Participants are monitored for reaccumulation of hematoma and the need for rescue surgical evacuation at various time points, including within 1 month and up to 24 months post-procedure. Clinical outcomes and complications are evaluated up to 24 months, with data collected on hospital stay duration, discharge condition, and any related complications. The study uses medical records and follow-up assessments to understand the long-term results of MMAE in treating cSDH.
CONDITIONS
Brief Title
Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Patients who have received endovascular embolization of the middle meningeal artery using any of the following materials: PVA particles, Onyx, nBCA glue, dimethyl sulfoxide, microcoils, or PVA with microcoils
You will not qualify if you...
- Patients who have received endovascular embolization of the middle meningeal artery using any embolization materials other than those listed in the inclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 24 months
Participants who have undergone middle meningeal artery embolization are observed for reaccumulation of hematoma, clinical outcomes, complications, and disposition after discharge over an extended period.
Follow-up visits within 1 month, between 1-3 months, 3-6 months, 6-12 months, and 12-24 months post procedure
Trial Site Locations
Total: 19 locations
1
Baptist Health South Florida, Inc.
Coral Gables, Florida, United States, 33143
Actively Recruiting
2
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
Completed
3
Orlando Regional Medical Center
Orlando, Florida, United States, 32806
Actively Recruiting
4
University of Illinois Chicago
Chicago, Illinois, United States, 60607
Completed
5
University of Chicago Medicine
Chicago, Illinois, United States, 60637
Actively Recruiting
6
The University of Iowa
Iowa City, Iowa, United States, 52242
Completed
7
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
8
Beth Israel Deaconess Medical Center (BIDMC)/Harvard Medical School
Boston, Massachusetts, United States, 02215
Actively Recruiting
9
Lahey Hospital and Medical Center
Burlington, Massachusetts, United States, 01805
Actively Recruiting
10
Mayo Clinic
Rochester, Minnesota, United States, 55905
Completed
11
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
12
Geisinger Health
Danville, Pennsylvania, United States, 17822
Completed
13
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19144
Actively Recruiting
14
UTHealth Houston
Houston, Texas, United States, 77030
Completed
15
HCA Houston Healthcare Kingwood
Kingwood, Texas, United States, 77339
Completed
16
Austin Health
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
17
Unity Health Toronto
Toronto, Ontario, Canada, M5C 2T2
Completed
18
University of Toronto
Toronto, Ontario, Canada, M5S 1A1
Actively Recruiting
19
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Completed
Research Team
M
Muhammed Amir Essibayi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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