Actively Recruiting
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
Led by Aristotle University Of Thessaloniki · Updated on 2026-03-30
1300
Participants Needed
13
Research Sites
357 weeks
Total Duration
On this page
Sponsors
A
Aristotle University Of Thessaloniki
Lead Sponsor
M
Minimal Invasive Extracorporeal Technologies International Society (MiECTiS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related postoperative morbidity after cardiac surgery. The study will be led by the Clinical Research Unit of the Special Unit for Biomedical Research and Education (SUBRE), Aristotle University of Thessaloniki School of Medicine in Greece (AUSoM) with Chief Investigator Professor Kyriakos Anastasiadis, who is a key-opinion-leader in the field of MiECC, founder and Executive Board of MiECTiS.
CONDITIONS
Official Title
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR), or both using extracorporeal circulation without circulatory arrest
You will not qualify if you...
- Requirement for emergency or salvage operation
- Requirement for major aortic surgery such as aortic root replacement
- Contraindication or objection to blood transfusion, including Jehovah's Witnesses
- Presence of congenital or acquired platelet, red cell, or clotting disorders (iron deficient anaemia patients allowed)
- Inability to give informed consent due to learning or language difficulties
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Perfusion Services University Health Network, Toronto General Hospital
Toronto, Canada, M5G 2C4
Actively Recruiting
2
Department of Cardiac Surgery
Coswig, Germany, 06869
Active, Not Recruiting
3
Department of Thoracic and Cardiovascular Surgery, University Medical Centre Goettingen
Göttingen, Germany
Active, Not Recruiting
4
Department of Cardiothoracic and Vascular Surgery, Ulm University Hospital
Ulm, Germany, 89081
Completed
5
Cardiothoracic Department AHEPA University Hospital
Thessaloniki, Greece, 54636
Actively Recruiting
6
Department of Cardiac Surgery GVM Anthea Hospital
Bari, Italy, 70124
Actively Recruiting
7
Department of Cardiac Surgery GVM Maria Eleonora Hospital
Palermo, Italy, 90135
Active, Not Recruiting
8
Department of Cardiovascular Surgery, Ankara City Hospital
Ankara, Turkey (Türkiye)
Active, Not Recruiting
9
Department of Cardiovascular Surgery, Izmir Bakırçay University, Faculty of Medicine
Izmir, Turkey (Türkiye)
Actively Recruiting
10
Department of Cardiovascular Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University
Rize, Turkey (Türkiye)
Actively Recruiting
11
Department of Cardiac Surgery, Royal Papworth Hospital
Cambridge, United Kingdom, CB2 0AY
Active, Not Recruiting
12
Deparment of Cardiac Surgery, Castle Hill Hospital
Hull, United Kingdom, HU16 5JQ
Active, Not Recruiting
13
Department of Cardiothoracic Surgery, Hammersmith Hospital
London, United Kingdom, W120HS
Active, Not Recruiting
Research Team
G
Georgios Papazisis, Assoc. Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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