Actively Recruiting
Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries
Led by VA Office of Research and Development · Updated on 2025-09-22
24
Participants Needed
1
Research Sites
212 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
J
John D. Dingell VA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The prevalence of autonomic dysfunction and sleep disordered breathing (SDB) is increased in individuals with spinal cord injury (SCI). The loss of autonomic control results in autonomic dysreflexia (AD) and orthostatic hypotension (OH) which explains the increase in cardiovascular related mortality in these Veterans. There is no effective prophylaxis for autonomic dysfunction. The lack of prophylactic treatment for autonomic dysfunction, and no best clinical practices for SDB in SCI, are significant health concerns for Veterans with SCI. Therefore, the investigators will investigate the effectiveness of mild intermittent hypoxia (MIH) as a prophylactic for autonomic dysfunction in patients with SCI. The investigators propose that MIH targets several mechanisms associated with autonomic control and the co-morbidities associated with SDB. Specifically, exposure to MIH will promote restoration of homeostatic BP control, which would be beneficial to participation in daily activities and independence in those with SCI.
CONDITIONS
Official Title
Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-60 years
- Motor incomplete spinal cord injury at or above the 12th thoracic vertebrae
- Signs or symptoms of autonomic dysfunction based on specific questionnaire scores
- Chronic spinal cord injuries more than 1 year post injury
You will not qualify if you...
- Pregnant
- Smoker
- Drug addiction
- Younger than 18 or older than 60 years
- Complete spinal cord injury
- Spinal cord injury below the 6th thoracic vertebrae
- Insulin dependent diabetes
- Shift workers with disrupted circadian rhythm
- Active skin breakdown or pressure sores
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201-1916
Actively Recruiting
Research Team
G
Gino Panza, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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