Actively Recruiting
Milk Consumption and Blood Microbiome in Healthy Volunteers
Led by Erasmus Medical Center · Updated on 2025-08-07
10
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
Sponsors
E
Erasmus Medical Center
Lead Sponsor
N
NWO (Dutch Organisation for Scientific Research)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn if cfDNA of milk-associated intestinal bacteria (MAIB) is detectable in the bloodstream. The primary question it aims to answer is: \- Does milk consumption simultaneously increase the number of MAIB cfDNA counts in blood samples, as it does in fecal samples? Researchers will compare cfDNA counts of MAIB to those of fecal samples to assess whether the blood microbiome is a valid measure of the gut microbiome, utilizing a self-developed bioinformatics pipeline. Participants will: * Abstain from consuming any dairy products for ten days, followed by drinking milk for 7 consecutive days. * Provide blood and fecal samples before dairy abstinence, as well as at 0, 24, and 48 hours, and one week after the reintroduction of milk.
CONDITIONS
Official Title
Milk Consumption and Blood Microbiome in Healthy Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- Body mass index (BMI) between 18.5 and 25 kg/m2
- All genders are eligible
- Not lactose intolerant
- Willing to consume milk
You will not qualify if you...
- Regular use of antibiotics, steroids, beta blockers, or adrenergic-stimulating agents
- Regular use of prebiotics or probiotics other than yogurt and young soft cheese
- Antibiotic use in the previous months
- Smoking more than 10 cigarettes daily
- Having chronic diseases such as type 2 diabetes, hypertension, fatty liver disease, cancer, or autoimmune disease
- Having internal diseases affecting gastrointestinal tract, lungs, heart, blood vessels, liver, or kidneys
- Eating disorders or unusual eating habits
- Participation in another study
- Pregnancy or breastfeeding for women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Erasmus MC - Department of Gastroenterology and Hepatology
Rotterdam, Netherlands, 3015 GD
Actively Recruiting
Research Team
P
Prof. Dr. Maikel P. Peppelenbosch, MD, PhD
CONTACT
J
Junhong Su, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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