Actively Recruiting
MIMA Pilot Study: Microstructure of the Medial Temporal Lobe in Early Alzheimer's Disease
Led by Rennes University Hospital · Updated on 2026-03-30
50
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating early markers of Alzheimer's disease in patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD). The study aims to identify affordable and non-invasive biomarkers combined with cognitive assessments to detect early changes linked to Alzheimer's, focusing on gray matter microstructural changes in the medial temporal lobe. This research addresses the need for precise and accessible diagnostic tools that go beyond costly or invasive current methods like imaging or protein assays. The study uses advanced high-resolution diffusion MRI combined with cognitive tests targeting specific brain regions related to memory, such as the '4 mountains test' and the 'Memory entities' test. It involves 25 patients with subjective cognitive decline-plus and 25 patients with mild neurocognitive impairment due to Alzheimer's disease. Healthy volunteers were included in a separate study. The imaging and cognitive assessments are designed to evaluate microstructural brain changes and their relation to memory function. Participants will undergo diffusion MRI scans and cognitive testing lasting about 2 hours and 30 minutes. Researchers will measure MRI-based parameters of medial temporal lobe microstructure and explore their relationship with memory performance. The study includes assessments of memory functions linked to specific brain areas and monitors participants over the study duration to understand early Alzheimer's markers better. The total participation duration aligns with the assessment timings and study procedures.
CONDITIONS
Brief Title
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 50 and 80 years
- Native French speaking
- Right-handed
- Education level equal to or higher than primary school leaving certificate
- Free of any medical or psychiatric condition likely to interfere with cognition other than SCD or MCI
- Affiliated with a social security scheme
- Provided oral and written informed consent to participate
- Diagnosed with subjective cognitive decline-plus or mild neurocognitive impairment due to Alzheimer's disease
You will not qualify if you...
- Contraindications to MRI (e.g., large abdominal circumference, implanted pacemaker, neurosurgical clips, cochlear implants, metallic foreign bodies, recent prostheses or devices, claustrophobia)
- Sensory deficits interfering with experimental tests
- Pregnant or breastfeeding women
- Adults under legal protection or deprived of liberty
- Modified Hachinski ischemic score greater than 2
- Diagnosis of dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2 hours and 30 minutes per session
Participants undergo high-resolution diffusion MRI and cognitive assessments to evaluate medial temporal lobe microstructure and function.
1 visit (in-person)
Duration - Up to study completion
Participants are monitored for changes related to medial temporal lobe microstructure and cognitive function over time.
Additional assessments may occur depending on cohort assignment
Trial Site Locations
Total: 1 location
1
CHU Rennes
Rennes, France
Actively Recruiting
Research Team
P
Pierre-Yves JONIN, PhD
I
Isabelle LEROYER
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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