Actively Recruiting
Mind-wandering and Predictive Processes in Narcolepsy A Study of REM Sleep Intrusions During Wakefulness
Led by Hospices Civils de Lyon · Updated on 2025-01-13
180
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining how mind wandering, a state where attention shifts from external tasks to internal thoughts, affects cognitive performance. This study focuses on patients with narcolepsy type 1 (NT1), idiopathic hypersomnia (IH), and subjective hypersomnolence to explore the role of REM sleep intrusions during wakefulness in triggering mind wandering. The study aims to understand whether mind wandering is more frequent and differently affects performance in NT1 patients compared to those with IH or subjective hypersomnolence, using the Alternating Serial Reaction Time Task (ASRT). The ASRT involves responding to visual stimuli appearing in different screen locations by pressing corresponding keys. The task includes a probabilistic sequence of stimuli with alternating pattern and random elements, performed in 25 blocks. After each block, participants take short breaks and answer thought probes. Participants complete the ASRT once. Additionally, several questionnaires assessing mind wandering, sleepiness, narcolepsy severity, anxiety, depression, sleep quality, insomnia, and psychotic-like experiences are completed at the study's start. A subset of participants will also have electrophysiological recordings during the ASRT. Participants are involved in performing the ASRT task while researchers measure accuracy and reaction time differences between high- and low-probability trials. Questionnaires provide additional information on sleep and cognitive states. Electrophysiological data from a subset help explore sleep intrusions during wakefulness. The study monitors cognitive performance and mind wandering characteristics to better understand the impact of covert REM intrusions in hypersomnolence disorders.
CONDITIONS
Official Title
Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with Narcolepsy Type 1 or Idiopathic Hypersomnia according to ICSD3-TR criteria
- For Idiopathic Hypersomnia patients: abnormal Mean Sleep Latency Test with mean latency 64 8 minutes and 64 1 SOREMp
- Patients with subjective hypersomnolence without underlying cause confirmed by negative extensive medical work-up including actigraphy, polysomnography, MSLT, 24-hour bedrest, biological tests, MRI, and psychiatric consultation
You will not qualify if you...
- Cognitive impairment that prevents task completion
- Current treatment with antidepressants
- Other causes of hypersomnolence such as untreated severe obstructive sleep apnea, circadian rhythm disorders, sleep deprivation, somatic or psychiatric causes, or sedative substance intake
- Unstable medical or psychiatric conditions
- Refusal to participate
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hôpital de la Croix-Rousse
Lyon, France, 69004
Actively Recruiting
Research Team
L
Laure PETER-DEREX, Professor
D
Dezső NEMETH, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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