Actively Recruiting
Mindfulness for Cognition in Early-stage Alzheimer's Disease
Led by VA Boston Healthcare System · Updated on 2025-01-27
100
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.
CONDITIONS
Official Title
Mindfulness for Cognition in Early-stage Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy older adults with cognitive performance within 1.0 standard deviation for age and education norms on neuropsychological tests
- Mild cognitive impairment participants with delayed recall or other cognitive domain scores worse than 1.5 standard deviations for age and education norms
- Mini-Mental State Examination (MMSE) score between 25 and 30
- Montreal Cognitive Assessment (MoCA) score between 20 and 30
You will not qualify if you...
- No access to a computer, smartphone, or internet
- Unable to understand informed consent or have moderate dementia
- Mood disorders (e.g., PTSD, depression, anxiety) or alcohol and drug use interfering with daily life or requiring hospitalization within past 5 years
- Cerebrovascular disease
- Medical conditions severely impairing cognition such as stroke, frontotemporal dementia, or Parkinson's disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Boston Healthcare System - Jamaica Plain Campus
Boston, Massachusetts, United States, 02130
Actively Recruiting
Research Team
K
Katherine W Turk, MD
CONTACT
K
Kathy Y Xie, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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