Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07466966

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Led by St. Anne's University Hospital Brno, Czech Republic · Updated on 2026-03-13

106

Participants Needed

1

Research Sites

117 weeks

Total Duration

On this page

Sponsors

S

St. Anne's University Hospital Brno, Czech Republic

Lead Sponsor

K

King's College London

Collaborating Sponsor

AI-Summary

What this Trial Is About

This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.

CONDITIONS

Official Title

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Diagnosis of peri-implantitis with probing pocket depth greater than 6 mm, bleeding on probing, and bone loss of 3 mm or more
  • Implant surface accessible without removing suprastructure
  • Full mouth plaque score less than 30% and full mouth bleeding score less than 30-35%
Not Eligible

You will not qualify if you...

  • Use of antibiotics in the last 3 months
  • Pregnancy or lactation
  • Uncontrolled diabetes with HbA1c of 7 or higher
  • Long-term systemic peri-implant care longer than 2 years
  • Previous implant therapy less than 12 months ago
  • Smoking or vaping in the last 12 months
  • Hopeless implant condition
  • Need for additional antibiotic treatment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Syndenta s.r.o., Hlinky 92, 603 00 Brno, Czech Republic

Brno, Czechia, 60300

Actively Recruiting

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Research Team

M

MDDr. Filip Hromčík, Ph.D., MDDr., Ph.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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