Actively Recruiting
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
Led by M.D. Anderson Cancer Center · Updated on 2026-03-05
580
Participants Needed
19
Research Sites
438 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery (neoadjuvant chemotherapy). MIS is a surgical procedure that uses small incision(s) and is intended to produce minimal blood loss and pain for the patient. Laparotomy is a surgical procedure which allows the doctors to remove some or all of the tumor and check if the disease has spread to other organs in the body. MIS may work the same or better than standard laparotomy after chemotherapy in prolonging the return of the disease and/or improving quality of life after surgery.
CONDITIONS
Official Title
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Stage IIIC or IV high-grade (serous, endometrioid, clear-cell, transitional) invasive epithelial ovarian, primary peritoneal, or fallopian-tube carcinoma or high-grade mullerian carcinoma
- Considered a surgical candidate after 3 to 4 cycles of platinum-based or investigational neoadjuvant chemotherapy with complete radiologic resolution outside the abdomen
- Normalized CA-125 or CA-125 ≤ 500 U/mL with planned diagnostic laparoscopy
- Interval debulking surgery planned within 6 weeks after last chemotherapy cycle
- ECOG performance status 0 to 2
- Signed informed consent and ability to comply with follow-up
- Negative pregnancy test within 14 days prior to surgery
- No active other malignancies in past 5 years except certain skin cancers
You will not qualify if you...
- Tumor not suitable for minimally invasive surgery based on pre-operative imaging including unresolved ascites, involvement of small bowel, stomach, colon, rectum, diaphragm, spleen, liver, mesentery, or lesser peritoneal sac
- Psychological, familial, sociological, or geographical conditions preventing compliance
- Unable to tolerate prolonged Trendelenburg position or pneumoperitoneum
- Any other clinician-assessed contraindication to minimally invasive surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
2
Cleveland Clinic Foundation - Florida
Weston, Florida, United States, 33331
Actively Recruiting
3
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
4
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
5
NYU Langone Health
Mineola, New York, United States, 11501
Actively Recruiting
6
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
7
Duke
Durham, North Carolina, United States, 27710
Actively Recruiting
8
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
9
St. Luke's University Health Network
Bethlehem, Pennsylvania, United States, 18015
Actively Recruiting
10
Lyndon Baines Johnson General
Houston, Texas, United States, 77026
Actively Recruiting
11
Houston Methodist
Houston, Texas, United States, 77030
Actively Recruiting
12
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
13
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States, 53792
Active, Not Recruiting
14
Arthur J.E. Child Comprehensive Cancer Centre - Calgary
Calgary, Canada
Actively Recruiting
15
University Health Network - Princess Margaret Cancer Centre
Toronto, Canada
Actively Recruiting
16
Sant'Orsola Hospital di Bologna
Bologna, Italy, 40138
Actively Recruiting
17
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy, 00168
Actively Recruiting
18
Instituto Nacional de Cancerología (Mexico)
Tlalpan, Mexico
Actively Recruiting
19
Amsterdam UMC - Locatie AMC | H5Zuid 154
Amsterdam, Netherlands
Actively Recruiting
Research Team
J
Jose A. Rauh-Hain, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here