Actively Recruiting

Phase 2
Age: 0 - 24Hours
All Genders
NCT06975189

MINImising Total Radiation EXposure in Preterm Infants

Led by Western Health, Australia · Updated on 2026-04-16

180

Participants Needed

1

Research Sites

189 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive. Despite this significant global impact, neonatal clinicians have few tools available to guide breathing support. Currently, the only lung imaging tool that is routinely used in the Neonatal Intensive Care Unit is a chest X-ray. To reduce radiation exposure, chest X-rays are usually only performed one or two times a day. As chronic lung disease in babies who survive preterm birth is increasing, there is an urgent need to develop new ways to monitor the lungs of these fragile babies. Lung ultrasound is a form of imaging that is fast, gentle and radiation free. However, it has not been routinely adopted into caring for preterm babies in most countries. This is because there are no randomised controlled trials that have demonstrated the benefit and safety of using lung ultrasound as the first-line imaging tool in preterm babies. The investigators will conduct a randomised controlled trial to demonstrate that lung ultrasound is a quick, safe and accurate alternative to chest x-rays in preterm babies.

CONDITIONS

Official Title

MINImising Total Radiation EXposure in Preterm Infants

Who Can Participate

Age: 0 - 24Hours
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Infant born from 22 to 31 weeks and 6 days gestation
  • Infant admitted to Neonatal Intensive Care Unit
  • Infant requires lung imaging for respiratory issues
  • Parent or guardian can provide informed consent
Not Eligible

You will not qualify if you...

  • Chest X-ray only needed to confirm device positions (e.g., central line, endotracheal tube)
  • Chest X-ray only needed for non-respiratory reasons (e.g., heart assessment)
  • Clinician concerned about baby's stability for ultrasound
  • Baby's skin cannot tolerate ultrasound gel
  • Parent or guardian refuses or cannot provide informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Joan Kirner Women's and Children's, Sunshine Hospital, Western Health

Melbourne, Victoria, Australia, 3021

Actively Recruiting

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Research Team

A

Arun Sett, PhD

CONTACT

N

Niranjan Abraham, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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