Actively Recruiting
Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery
Led by Beijing Tiantan Hospital · Updated on 2025-07-16
535
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Incisional pain is a common complication after surgery and is an important cause of delayed postoperative recovery, increased length of hospital stay, increased risk of wound infection and respiratory/cardiovascular complications, as well as an important medical, social, and economic problem. Prevention and treatment of postoperative incision pain remains challenging. Local Infiltration Anaesthesia (LIA) for surgical incisions with an anti-inflammatory and analgesic combination has been reported to be effective in reducing postoperative pain, but there is a gap in the research on the optimal concentration of anti-inflammatory drugs in the anti-inflammatory and analgesic combination during local infiltration. The aim of this study was to investigate the optimal concentration of anti-inflammatory drugs in the anti-inflammatory-analgesic combination solution used for local infiltration of spinal surgical incisions to prevent postoperative pain.
CONDITIONS
Official Title
Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for spine surgery under general anesthesia involving cervical, thoracic, or lumbar regions within three levels
- Age between 18 and 65 years
- American Society of Anaesthesiologists Classification I or II
You will not qualify if you...
- Patients who refuse to participate
- Allergy to ropivacaine, betamethasone, or opioids
- History of drug or alcohol abuse
- Abnormal kidney or liver function tests
- Body mass index less than 15 kg/m2 or greater than 35 kg/m2
- History of spinal surgery
- Presence of peri-incisional infection
- History of stroke or serious neurological disease
- History of diabetes or other metabolic disorders
- History of psychological disorders
- Current use of systemic steroids
- Pregnant or breastfeeding
- Glasgow Coma Scale score less than 15 before surgery
- Unable to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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