Actively Recruiting

Phase Not Applicable
Age: 18Years - 60Years
All Genders
NCT07326943

Minimum Effective Dose of Ropivacaine for Ultrasound-guided Interscalene Block

Led by Huazhong University of Science and Technology · Updated on 2026-04-03

56

Participants Needed

1

Research Sites

65 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Inter muscular groove brachial plexus block is a commonly used peripheral nerve block technique in clinical practice, commonly used for anesthesia and analgesia in clavicle, shoulder, and humeral surgeries. The classic ultrasound-guided intermuscular groove block also involves puncturing the needle to the level of the C5/C6 anterior branch for drug injection. After injection, local anesthetics mainly wrap around C5, C6, and some C7 nerve roots. Therefore, intermuscular groove block is mainly used for shoulder, humerus, and clavicle surgery. Due to incomplete ulnar block, it is not recommended for surgery on the elbow joint and its distal end.Scholars have found that using C5 as the puncture target to implement intermuscular groove block and administering 10ml of 0.75% ropivacaine, the success rate of ulnar nerve block is 19%. The success rate of ulnar nerve block with C6 as the puncture target was 93% when 10ml of 0.75% ropivacaine was administered. This suggests that blockade methods closer to the tail muscle groove on the tail side have a higher success rate for blocking the C7, C8, and T1 nerve roots. In our clinical work, the investigators found that when performing intermuscular groove block with C7 nerve root as the puncture target, local anesthetics not only stably wrap around C7 nerve root, but also spread to wrap around C5 and C6 nerve roots on the head side, and spread to the deep surface of the brachial plexus trunk on the tail side. Local anesthetic diffusion can also be seen in some patients at the brachial plexus bundle in the intercostal space. From the perspective of local anesthetic diffusion patterns, intermuscular groove block targeting the C7 nerve root may cover the anterior branches of C5, C6, C7, C8, and T1 nerve roots, achieving complete brachial plexus block. Preliminary clinical practice suggests that C7 intermuscular groove block can be used for forearm and hand surgery. Successful C7 intermuscular groove block relies on the diffusion and wrapping of local anesthetics around the anterior branches of C5, C6, and C7 nerve roots, as well as the inferior trunk of the brachial plexus (or the anterior branches of C8 and T1 nerve roots).Therefore, the investigators designed this study to determine the amount of local anesthetic required to achieve stable forearm and hand block during C7 intermuscular groove block.

CONDITIONS

Official Title

Minimum Effective Dose of Ropivacaine for Ultrasound-guided Interscalene Block

Who Can Participate

Age: 18Years - 60Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 60 years
  • ASA physical status I or II
  • Body mass index between 18 and 30 kg/m2
  • Patients scheduled for hand or forearm surgery
  • Signed informed consent form
Not Eligible

You will not qualify if you...

  • Refusal to participate in the study
  • Presence of peripheral nerve diseases
  • Allergy to lidocaine or ropivacaine
  • Pregnancy
  • Obstructive or restrictive lung disease
  • Coagulation problems
  • Long-term opioid use
  • Infection, tumor, or previous surgery at the puncture site

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Trial Site Locations

Total: 1 location

1

Shanxi Bethune Hospital

Taiyuan, Shanxi, China, 030032

Actively Recruiting

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Research Team

H

Huailiang LI,

CONTACT

Z

Zheng Hua, Study Principal Investigator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

NON_RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

2

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