Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
ID04941664

Minimum Effective Local Anesthetic Volume of 0.5% Levobupivacaine Required for Ultrasound Guided Superior Trunk Block for Shoulder Surgery

Led by Chinese University of Hong Kong · Updated on 2025-04-13

25

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying the minimum effective dose of levobupivacaine, a common local anesthetic, needed to provide effective pain relief through an ultrasound-guided superior trunk block for shoulder arthroscopic surgeries. This approach aims to reduce the risk of hemi-diaphragmatic palsy that can occur with the currently used interscalene brachial plexus block, by targeting the superior trunk of the brachial plexus where most shoulder innervation occurs. The study focuses on achieving effective anesthesia in at least 90% of patients. In this study, participants scheduled for shoulder surgery will receive an ultrasound-guided superior trunk nerve block with 0.5% levobupivacaine. The initial dose is 8 ml, which may be adjusted up or down by 2 ml for subsequent patients depending on the success of the block, with a maximum dose of 16 ml and a minimum of 4 ml. This dose-finding method uses the Modified Narayana rule to determine the minimum effective volume. Participants will be monitored for sensory and motor block changes of the upper extremity at 5-minute intervals for 45 minutes after the block to assess readiness for surgery. The study will also evaluate diaphragmatic function before and 30 minutes after the block, block performance time, discomfort scores, and any complications or paresthesia during the procedure. The aim is to find the lowest dose that provides effective anesthesia with minimal side effects during shoulder arthroscopic surgery.

CONDITIONS

Brief Title

Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 75 years
  • American Society of Anesthesiologists (ASA) physical status I-III
  • Scheduled to undergo elective upper shoulder arthroscopic rotator cuff repair procedure
Not Eligible

You will not qualify if you...

  • Patient refusal
  • Pregnancy
  • Skin infection at the site of block placement
  • History of allergy to local anaesthetic drugs
  • Bleeding tendency or evidence of coagulopathy
  • Pre-existing neurological deficit or neuromuscular disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Treatment

Duration - Single day around surgery

Participants receive an ultrasound guided superior trunk block with 0.5% levobupivacaine to produce surgical anesthesia or analgesia for shoulder surgery. The local anesthetic volume is adjusted based on the effectiveness of the block.

1 visit (in-person) for block administration and assessment

Trial Site Locations

Total: 1 location

1

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital

Shatin, New Territories, Hong Kong

Actively Recruiting

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Research Team

A

Ayla Wong, RN, BN

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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