Actively Recruiting
Minocycline for Chronic Autoimmune Uveitis
Led by Sun Yat-sen University · Updated on 2023-04-18
10
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.
CONDITIONS
Official Title
Minocycline for Chronic Autoimmune Uveitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with autoimmune disease causing vision damage (decreased BCVA or retinal structure loss)
- Aged 18 to 60 years old
- Signed informed consent and able to complete all study visits
You will not qualify if you...
- Allergy to minocycline or tetracycline antibiotics
- Abnormal liver, heart, kidney, or thyroid function
- Currently using glucocorticoids, immunosuppressants, or biologics
- Pregnant, breastfeeding, or planning pregnancy
- Using other medications for different diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongshan Ophthalmic Center
Guangzhou, Guangdong, China, 510000
Actively Recruiting
Research Team
D
Dan Liang
CONTACT
Y
Yuxi Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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