Actively Recruiting
miRNA in Septic Acute Kidney Injury
Led by University Hospital Ostrava · Updated on 2024-07-12
220
Participants Needed
2
Research Sites
191 weeks
Total Duration
On this page
Sponsors
U
University Hospital Ostrava
Lead Sponsor
U
University Hospital Olomouc
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition. The exact pathophysiological mechanism of septic acute kidney injury remains a challenge. One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells. The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury. And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury.
CONDITIONS
Official Title
miRNA in Septic Acute Kidney Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults older than 18 years
- Newly diagnosed sepsis or septic shock, with or without acute kidney injury
- Healthy volunteers with no signs of infection on clinical or laboratory tests
- Signed informed consent
You will not qualify if you...
- Under 18 years old
- Chronic kidney disease stage 4 or 5 according to KDIGO guidelines
- Patients on chronic dialysis or after kidney transplantation
- Healthy volunteers with acute or chronic infection
- Healthy volunteers with kidney disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia, 708 52
Actively Recruiting
2
University Hospital Olomouc
Olomouc, Olomouc Region, Czechia, 779 00
Actively Recruiting
Research Team
J
Jiří Hynčica
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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