Actively Recruiting
miRNAs in Critical Limb Ischemia (miRNACLI)
Led by IRCCS Policlinico S. Donato · Updated on 2025-04-30
80
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For the present study, 40 patients affected by critical limb ischemia of different severity will be enrolled: patients affected by critical limb ischemia undergoing subgenual femoropopliteal bypass; patients suffering from terminal ischemia causing gangrene and therefore undergoing major amputation of the lower limb. Biopsies from the first 20 enrolled patients will be used for miRNA profiling. The total of 40 biopsies obtained from all enrolled patients will instead be used for the validation of the miRNAs identified in the profiling. The results obtained will be compared with those obtained in 40 control patients affected by infrarenal abdominal aortic aneurysm (AAA) undergoing endovascular exclusion surgery (EVAR) of the AAA without any ischemia of the lower limbs. Also in this case the biopsies of the first 20 control patients enrolled will be used for miRNA profiling. The total of 40 biopsies obtained from all control patients will instead be used for the validation of the miRNAs identified in the profiling. A total of 80 patients (40 cases and 40 controls) will be enrolled.
CONDITIONS
Official Title
miRNAs in Critical Limb Ischemia (miRNACLI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with critical limb ischemia scheduled for popliteal exploration surgery and/or subgenual femoropopliteal bypass
- Patients with critical limb ischemia and irreversible ischemia or distal gangrene of the lower limb scheduled for major amputation
- Patients with infrarenal abdominal aortic aneurysm undergoing endovascular exclusion surgery (EVAR) who do not have critical limb ischemia, including those with or without type 2 diabetes mellitus
You will not qualify if you...
- Pregnant women
- Patients with genetic diseases
- Patients with malignant neoplasia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy, 20097
Actively Recruiting
Research Team
F
Fabio Dr Martelli
CONTACT
G
Giovanni Dr Nano, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here