Actively Recruiting
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Led by Washington University School of Medicine · Updated on 2026-04-29
46
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.
CONDITIONS
Official Title
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English-speaking
- Elective non-cardiac or non-intracranial surgery requiring at least a 2-day hospital stay
You will not qualify if you...
- Received investigational drug within the last 7 weeks
- Lack of capacity to provide informed consent
- Known intolerance or allergy to SSRIs or fluvoxamine
- Planned postoperative ventilation
- Drug or alcohol dependence
- Preoperative use of certain medications with serious drug interactions (Class X or D)
- Risk of serotonin syndrome due to use of St John's Wort, SSRIs, or TCA medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
S
Sarah Knarr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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