Actively Recruiting
Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation
Led by Michael J. Wesley, PhD · Updated on 2025-11-05
12
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main questions the study aims to answer are: * Does brain stimulation change how people behave after drinking alcohol? * Does the combination of alcohol and different types of brain stimulation affect people's ability to make thoughtful decisions or resist impulses? Researchers will compare the effects of two types of brain stimulation, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), after people drink alcohol or a placebo drink. A sham (placebo) stimulation condition will also be included. The study uses a within-person design, which means each participant will take part in all conditions. Participants will: * Attend five separate study visits * Drink either an alcoholic or placebo beverage * Receive one of the brain stimulation conditions (real or sham) * Complete decision-making tasks before and after drinking The tasks will measure things like impulsive choices and reaction time. The researchers hope this study will help identify how brain stimulation could be used to improve decision-making during intoxication, which might one day reduce harmful drinking behaviors or prevent alcohol-related accidents.
CONDITIONS
Official Title
Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 to 29 years
- Competent in English
- Body mass index between 19 and 26
- At least a high school education
- Moderate alcohol use without alcohol use disorder
- Negative urine drug screen for illicit drugs
- Negative urine pregnancy test if applicable on testing days
You will not qualify if you...
- History of seizures or first-degree relative with seizure history
- History of head trauma or other central nervous system injuries
- Current or past psychiatric disorders including substance use disorder except nicotine or caffeine
- Contraindications for non-invasive brain stimulation such as metal implants or pacemaker
- Currently pregnant or breastfeeding
- Use of medications that lower seizure threshold
- Positive symptoms of alcohol withdrawal
- Smoking more than five cigarettes per day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40507
Actively Recruiting
Research Team
M
Michael J. Wesley, Ph.D.
CONTACT
M
Mark T. Fillmore, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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