Actively Recruiting
Mitigating the Pro-inflammatory Phenotype of Obesity
Led by University of Kansas Medical Center · Updated on 2025-06-05
60
Participants Needed
1
Research Sites
317 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo.
CONDITIONS
Official Title
Mitigating the Pro-inflammatory Phenotype of Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or Female, age 18-79
- Obese: BMI > 30 m/kg2
- Hypertensive: blood pressure >130/80
- Elevated insulin resistance (HOMA-IR > 2.5)
- Waist circumference >102 cm (men) and >88 cm (women)
- Fasting glucose < 126 mg/dL
- Fasting triglycerides < 250 mg/dL
- HbA1c < 6.5%
- Willing to visit research lab (Fairway CTSU)
- Willing to undergo a blood draw
- Able to provide written informed consent
You will not qualify if you...
- Current use of clonidine or beta-blockers
- Current smoker or History of smoking in the past 3 months.
- Hyperlipidemia: Fasting triglycerides > 250 mg/dL
- Currently taking hypertension medication
- History of heart disease (e.g., myocardial infarction, stent, bypass, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
- History of neurological disorders
- History of transplant
- Actively participating in other studies, except for a registry study.
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66103
Actively Recruiting
Research Team
S
Seth W Holwerda, Ph,D
CONTACT
D
Davina A Clonch
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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