Actively Recruiting
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
Led by Steadman Philippon Research Institute · Updated on 2024-03-12
120
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy of Losartan use post-operatively for reducing or preventing the development of arthrofibrosis and the associated adverse impacts on clinical outcomes.
CONDITIONS
Official Title
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Planned primary total knee arthroplasty of a single knee
- Male or female 18 years of age or older
- Able to personally give informed consent and willing to comply with all study procedures and assessments
You will not qualify if you...
- Breastfeeding, pregnant, or planning to become pregnant during the study
- Diagnosed with inflammatory or autoimmune arthritis affecting the study knee
- Previous knee arthroplasty on the study knee
- Previous infection affecting the study knee
- Planned total knee arthroplasty on the opposite knee during study participation
- Hypotension as confirmed by the investigator
- Planned lower extremity surgery other than the study knee replacement during participation
- Any condition other than knee osteoarthritis significantly impairing walking or daily activities
- Currently taking Losartan or similar drugs, or anticoagulants like Warfarin
- Opioid use in past 8 weeks without willingness to discontinue during study except post-op standard care
- Allergy to any ingredient of Losartan
- Taking medications known to interact adversely with Losartan
- Any medical condition posing risk or interfering with study participation as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Steadman Clinic
Vail, Colorado, United States, 81657
Actively Recruiting
Research Team
S
Suzanne L Page, JD
CONTACT
L
Luz Thede
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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