Actively Recruiting
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial
Led by Dallas VA Medical Center · Updated on 2025-08-24
60
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to investigate the validity of a previous clinical trial named EH301, which showed beneficial effects of anti-oxidant therapies in patients with amyotrophic lateral sclerosis (ALS). If validated by this study, providing over-the-counter anti-oxidants would be a simple, low risk, low-cost approach to significantly slow or stop the progression of ALS, for which currently no effective treatment exists. It is currently thought that oxidative stress is a major cause of ALS. The study investigators are therefore planning to expand the original scope of the previous trial by including anti-oxidants at high doses that were not previously used. All of these compounds are considered safe.
CONDITIONS
Official Title
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A clinical diagnosis of laboratory-supported probable, probable, or definite ALS by a study investigator according to a modified El Escorial criterion
- Age between 21 and 80 years inclusive
- If taking riluzole for ALS, must be on a stable dose for at least 30 days before baseline
- Willing and able to provide signed informed consent approved by the Institutional Review Board (IRB)
You will not qualify if you...
- Diagnosis of other neurodegenerative diseases such as Parkinson disease or Alzheimer disease
- History of unstable medical illness (e.g., unstable angina, advanced cancer) in the last 30 days
- Infection with human immunodeficiency virus (HIV)
- Limited mental capacity preventing informed consent or compliance with study procedures
- History of recent alcohol or drug abuse or noncompliance with treatment or other experimental protocols
- Receipt of any investigational drug within the past 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA North Texas Health Care System
Dallas, Texas, United States, 75216
Actively Recruiting
Research Team
R
Rehana Hussain, M.Sc.
CONTACT
S
Shirley OLeary, NP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here