Actively Recruiting
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-07-03
170
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the metabolomic biomarkers that may be at the origin of mitochondrial disturbances associated with the disease. This will be the first study combining functional analyses of mitochondria and exploratory metabolomic assessments in the same cohort at early stages of the disease.
CONDITIONS
Official Title
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Neurocognitive disorder with spontaneous or reported complaint lasting at least 6 months
- Diagnostic process following current Haute Autorité de Santé (HAS) recommendations
- Cerebrospinal fluid biomarker testing done at the study center with agreement for residual fluid bio-collection
- Patient has signed informed consent
- Patient is affiliated with or beneficiary of a social security scheme
- For Alzheimer's group: diagnosis per NIA-AA 2024 criteria with pathogenic amyloid process in cerebrospinal fluid
- For non-Alzheimer group: diagnosis of mild or major neurocognitive disorder per DSM-V criteria without pathogenic amyloid process in cerebrospinal fluid
You will not qualify if you...
- Vulnerable people
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Nice
Nice, PACA, France, 06000
Actively Recruiting
Research Team
J
Justine Lemaire
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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