Study of Mitochondrial Function in the Hearts of Adults with Heart Failure and Type 2 Diabetes Observing Heart Tissue and Metabolism to Understand Diabetic Heart Disease

What this Trial Is About

The trial investigates how diabetes, particularly type 2 diabetes mellitus T2DM, affects heart failure by studying the function of mitochondria in the heart muscle. Researchers aim to understand the changes in mitochondrial metabolism and how these relate to diabetic cardiomyopathy, a type of heart dysfunction seen in diabetic patients. This observational study focuses on patients with heart failure or those who have undergone heart transplantation, examining the underlying cellular mechanisms to guide early diagnosis and treatment strategies. Participants are grouped based on their heart failure status and presence of T2DM, including patients with manifest heart failure, terminal heart failure, and those after heart transplantation. The study collects heart tissue samples through biopsies or surgery to analyze mitochondrial function and related metabolic markers. Cardiac function is assessed using magnetic resonance imaging MRI with stress tests and magnetic resonance spectroscopy, along with oral glucose tolerance tests to evaluate glycemic control. Throughout the study, participants undergo various assessments including myocardial biopsies, imaging, and metabolic tests. Researchers measure the heart muscles mitochondrial oxidative capacity, cardiac structure and function markers, gene expression, and inflammation. Long-term clinical outcomes such as myocardial infarction, mortality, rejection after transplant, and hospitalization for heart failure are monitored for up to five years. This comprehensive approach aims to clarify how diabetes affects heart muscle metabolism and function over time.

Mitochondrial Substrate Utilization in the Diabetic Human Heart