Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations.
Daniel Buser, William Martin, Urs C Belser
https://pubmed.ncbi.nlm.nih.gov/15635945/Actively Recruiting
Led by Nova Southeastern University · Updated on 2025-09-12
30
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating a new grafting material combining demineralized freeze-dried bone allograft DFDBA and deproteinized bovine bone mineral DBBM for alveolar ridge preservation after tooth extraction. The study aims to compare this new combination to a commonly used mineralized allograft, focusing on changes in ridge dimensions and bone quality. This research addresses the challenge of preserving bone volume and vitality for successful future dental implants. Participants who need a premolar or molar extraction followed by implant placement will be randomly assigned to one of two groups. One group will receive the new graft combination of DFDBA and DBBM with a collagen matrix seal, while the other group will receive the traditional Tutoplast4 processed mineralized particulate allograft with a collagen matrix seal. The procedures will be performed flaplessly during the alveolar ridge preservation process. Over a 4-month healing period, researchers will measure changes in the horizontal and vertical dimensions of the alveolar ridge and assess the percentage of vital bone formed. Participants will be monitored for these outcomes to evaluate the effectiveness of the graft materials. The study includes assessments of possible factors affecting ridge changes and will last approximately 4 months from treatment to evaluation.
CONDITIONS
Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?
A
Andee Goldstein, DMD
F
Fatemeh Samavatijame, DMD
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Nova Southeastern University
Lead Sponsor
Geistlich Pharma AG
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Mix of demineralized freeze-dried bone allograft and deproteinized bovine bone mineral | Deproteinized bovine bone mineral alone |
|---|---|---|
| What it is | A bone-grafting approach combining demineralized freeze-dried bone allograft (DFDBA) and deproteinized bovine bone mineral (DBBM) to fill the socket after tooth extraction. | A bone-grafting approach using only deproteinized bovine bone mineral (DBBM) to fill the extraction socket following tooth removal. |
| Role in the trial | Investigational bone grafting mixture being evaluated for effectiveness and bone healing after tooth extraction. | Active comparator using deproteinized bovine bone mineral, a commonly used bone grafting material for socket preservation. |
| Primary use | To preserve bone volume and ridge shape after tooth extraction in preparation for future dental implant placement. | To maintain bone structure following extraction and support future implant placement by filling the socket with DBBM. |
| How it is performed | After tooth extraction without raising a surgical flap, the socket is filled with a combination of DFDBA and DBBM materials. | After flapless tooth extraction, only deproteinized bovine bone mineral is placed into the socket for ridge preservation. |
| Evidence status | There is ongoing research into whether mixing DFDBA with DBBM enhances new bone formation and ridge preservation; trial results are not yet available. | Deproteinized bovine bone mineral has a strong evidence base from randomized clinical trials and meta-analyses showing it limits bone loss after extraction and provides predictable socket preservation. |
| Important limitations | The benefit of using a mix of DFDBA and DBBM over single-material grafts for ridge preservation is not well established; results may vary by patient and protocol. Long-term outcomes and clinical utility remain to be confirmed. | Although DBBM is predictably effective for ridge preservation, residual graft particles may remain and the rate of vital bone formation may be lower compared to some alternatives. Healing can vary across patients. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure with 4 months of healing
Participants undergo flapless extraction followed by alveolar ridge preservation using one of two bone grafting materials to minimize ridge dimensional changes.
1 treatment visit and follow-up assessments over 4 months
Duration - At 4 months post-treatment
Participants return for evaluation of alveolar ridge dimensions and bone histology after 4 months of healing.
1 visit (in-person)
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/18605598/Nova Southeastern University
Lead Sponsor
Geistlich Pharma AG
Collaborating Sponsor