Actively Recruiting
3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
Led by Women's College Hospital · Updated on 2026-05-11
110
Participants Needed
1
Research Sites
40 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intrauterine device (IUD) insertion is a common contraceptive procedure often associated with moderate to severe pain, particularly among nulliparous individuals. Current pain management strategies, such as over-the-counter analgesics, are frequently inadequate. Methoxyflurane, a short-acting, self-administered inhaled analgesic, has been shown to provide rapid and effective pain relief in acute and procedural settings. This study aims to evaluate whether 3 mL of inhaled Methoxyflurane (via Penthrox inhaler) improves patient satisfaction by reducing pain and anxiety during IUD insertion.
CONDITIONS
Official Title
3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a uterus
- Ages 18 to 55 years
- Undergoing any intrauterine device (IUD) insertion
- English-speaking participants
- Ability to use an inhaler device
- Willing to receive a cervical block for their IUD insertion
You will not qualify if you...
- Unable to provide informed consent
- Confirmed pregnancy
- Use of pain medication other than NSAIDs or acetaminophen within 24 hours prior to intervention
- Use of cannabis within 24 hours prior to intervention
- Administration of misoprostol within 24 hours prior to intervention
- Altered level of consciousness from any cause
- History of severe reactions to Penthrox (methoxyflurane) or similar anesthetic agents
- Anatomical variance such as distorted uterine cavity, bicornuate uterus, uterus didelphys, or cervical stenosis
- Clinically significant kidney or liver impairment
- Known or genetic susceptibility to malignant hyperthermia
- Clinically evident hemodynamic or cardiovascular instability, or respiratory depression
- Not NPO according to hospital guidelines
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Women's College Hospital
Toronto, Ontario, Canada, M5S 1B2
Actively Recruiting
Research Team
D
Didem Bozak
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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