Actively Recruiting

Phase Not Applicable
All Genders
ID06094933

A Randomized Controlled Trial of the Mobile Anger Reduction Intervention for Veterans with PTSD and Problematic Anger

Led by VA Office of Research and Development · Updated on 2025-10-20

150

Participants Needed

1

Research Sites

21 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to evaluate a mobile health intervention for combat Veterans diagnosed with posttraumatic stress disorder (PTSD) who have difficulty controlling anger. Problematic anger in this group is linked to serious challenges such as social and work problems, family conflicts, aggression, and increased suicide risk. The study compares a new Mobile Anger Reduction Intervention (MARI), designed to reduce hostile interpretation bias, with a health education mobile app (HED) to see which better decreases anger and improves daily functioning. Participants will be randomly assigned to use either the MARI app or the HED app on their own smartphones for 4 weeks. The MARI app includes interpretation bias modification techniques, requiring at least five 10-minute sessions per week, plus tools like a nightly diary and progress tracking. The HED app provides videos on healthy habits and self-care, also used five times weekly. Both groups have equal usage expectations to compare effects fairly. Throughout the study, researchers will assess anger levels, hostile interpretation bias, social and occupational functioning, quality of life, and suicidal thoughts at the end of treatment, and at 3- and 6-month follow-ups. Participants' symptoms and app usage will be monitored, with outcomes measured to understand the impact of the mobile interventions. The total participation time includes the 4-week app use and subsequent follow-up assessments lasting up to 6 months after treatment starts.

CONDITIONS

Brief Title

Mobile Anger Reduction Intervention

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Veterans diagnosed with PTSD confirmed by chart review and a PTSD Checklist for DSM-5 (PCL-5) score of 33 or higher
  • Reporting a score of 12 or higher on the 5-item Dimensions of Anger Reactions Scale
  • No changes in type or dose of psychiatric medications for at least 3 months and no plans to change medications in the next 6 months
  • Able to read materials at or above a 6th grade level
Not Eligible

You will not qualify if you...

  • Currently experiencing active psychosis or mania
  • Having prominent suicidal or homicidal thoughts requiring immediate intervention
  • Previous use of the Mobile Anger Reduction Intervention app in another research study
  • Receiving or planning to receive other anger management or trauma-focused therapies for PTSD during the study period

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 screening and enrollment visit (in-person)

Outpatient Treatment

Duration - 4 weeks

Participants use a mobile application on their own smartphone to complete treatment sessions aimed at reducing anger and hostile interpretation bias.

Participants complete at least 5 sessions per week using the mobile app

Follow-up

Duration - 6 months

Participants are assessed for lasting effects on anger, hostile interpretation bias, psychosocial functioning, quality of life, and suicidal ideation.

Assessments at post-treatment, 3 months, and 6 months after treatment completion

Trial Site Locations

Total: 1 location

1

Durham VA Medical Center, Durham, NC

Durham, North Carolina, United States, 27705-3875

Actively Recruiting

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Research Team

K

Kirsten H Dillon, PhD

A

Angela C Kirby, MS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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