Actively Recruiting
A Mobile Gaming App to Improve Adherence to PrEP
Led by Rhode Island Hospital · Updated on 2025-05-14
200
Participants Needed
3
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study, the investigators will test the mobile game, Viral Combat, for efficacy and acceptability among diverse participants, ages 15-34 years, receiving PrEP care in clinical settings in New England and Mississippi. Formative evaluation interviews will be conducted with stakeholders (healthcare workers, clinic administrators, and patients taking PrEP) to inform intervention delivery. Data from the formative interviews will also be used to make necessary adaptations to the game and assess acceptability for diverse populations and clinics. Viral Combat will then be further tested with 200 participants ages 15-34 years, receiving PrEP care at clinical sites in the South (n=100 Jackson, MS) and New England (n=100, Providence, RI; Boston, MA) in a multisite Hybrid Type 1 effectiveness-implementation randomized controlled trial (RCT). This trial will test the efficacy of the intervention compared to a control condition (a non-PrEP related game) on biological and behavioral measures. At the end of the trial, a summative evaluation of the implementation context using the i-PARIHS framework will occur. These interviews with study participants and clinic staff will inform future implementation and dissemination of Viral Combat.
CONDITIONS
Official Title
A Mobile Gaming App to Improve Adherence to PrEP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 15 to 34 years
- English speaking
- Initiated PrEP in the last 30 days or restarted PrEP after not taking it for at least 1 month
- Confirmed HIV negative status by clinician and clinical record
- Able to give consent or assent and not impaired by cognitive or medical limitations as per clinical assessment
You will not qualify if you...
- None
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
2
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
3
Lifespan (The Miriam Hospital and Rhode Island Hospital)
Providence, Rhode Island, United States, 02904
Actively Recruiting
Research Team
L
Laura Whiteley, MD
CONTACT
J
James B Brock, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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