Actively Recruiting
Mobile Health Intervention to Improve Exercise in Pediatric PH
Led by Vanderbilt University Medical Center · Updated on 2026-03-27
50
Participants Needed
1
Research Sites
308 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt University Medical Center
Lead Sponsor
U
University of California, San Francisco
Collaborating Sponsor
AI-Summary
What this Trial Is About
Children and adults with pulmonary arterial hypertension (PAH) have severely reduced daily activity compared to healthy populations. In adults, investigators recently demonstrated that lower baseline daily step counts associated with increased risk of hospitalization and worsening WHO functional class; similarly, reduced step counts associate with hospitalization in children with PAH. This application builds on our recently completed NIH-funded pilot mobile health (mHealth) trial in adult patients with PAH which demonstrated the ability to remotely increase step counts. The investigators now aim to: (1) adapt our mHealth intervention to the developmental needs and interests of adolescents; and, (2) determine if our intervention increases step counts in adolescents, providing the foundation for a larger trial to assess the impact on quality of life and clinical outcomes.
CONDITIONS
Official Title
Mobile Health Intervention to Improve Exercise in Pediatric PH
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents between ages 10-21 years
- Diagnosed with WHO Group 1 PAH or WHO Group 4 PH (CTEPH)
- WHO functional class I-III
- Stable PAH-specific medication regimen for three months prior to enrollment, allowing only a single diuretic adjustment or adjustments in IV prostacyclin for side effect management
You will not qualify if you...
- Unable to perform normal activity due to wheelchair or bed bound status, reliance on cane/walker, or activity-limiting conditions such as angina or osteoarthritis
- Pregnancy
- Diagnosis of PAH other than idiopathic, heritable, or associated forms
- Functional class IV heart failure
- More than two diuretic adjustments in the prior three months
- Preferred activities not measurable by activity tracker (e.g., swimming, yoga, ice skating, stair master, bicycling, rollerblading)
- Participation in any other investigational intervention
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
N
Natasha Billard
CONTACT
E
Eric Austin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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