Actively Recruiting
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
Led by Priothera SAS · Updated on 2026-05-14
366
Participants Needed
108
Research Sites
385 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-center, randomized, double-blinded, placebo controlled trial.
CONDITIONS
Official Title
Mocravimod as Adjunctive and Maintenance Treatment in AML Patients Undergoing Allo-HCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of AML (excluding acute promyelocytic leukemia) according to WHO 2022 classification
- European Leukemia Net (ELN) high-risk or intermediate-risk AML in first complete remission (CR1), or AML of any risk in second complete remission (CR2), with CRi also allowed
- Planned allogeneic HCT from fully matched related or unrelated donor with no more than 1 antigen mismatch, or planned use of haploidentical donor using PBSC graft
- Any conditioning regimen with a Transplant Conditioning Score (TCI) greater than or equal to 1.5
- Planned use of tacrolimus (TAC)-based graft-versus-host disease (GvHD) prophylaxis
- Age between 18 and 75 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
You will not qualify if you...
- Use of cyclosporine A (CsA), anti-thymocyte globulin (ATG), alemtuzumab, or abatacept for GvHD prophylaxis
- Diagnosis of macular edema during screening
- Cardiac, pulmonary, hepatic, or renal dysfunction
- Hepatic dysfunction defined as AST and/or ALT greater than 2.5 times the upper limit of normal, or total bilirubin greater than 1.5 mg/dL
- Renal dysfunction with estimated creatinine clearance less than 45 mL/min by Cockcroft-Gault formula
- Diabetes mellitus
- History or presence of uveitis at screening
- History or diagnosis of macular edema
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 108 locations
1
University of Alabama Hospital (UAB Hospital)
Birmingham, Alabama, United States, 35233-1932
Actively Recruiting
2
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States, 85234-2165
Withdrawn
3
City of Hope Comprehensive Cancer Center - Duarte
Duarte, California, United States, 91010
Actively Recruiting
4
University of California Los Angeles (UCLA) - David Geffen School of Medicine
Los Angeles, California, United States, 90095
Actively Recruiting
5
UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center
Aurora, Colorado, United States, 80045
Withdrawn
6
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
7
Emory University - Winship Cancer Institute (WCI)
Atlanta, Georgia, United States, 30322-1013
Actively Recruiting
8
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
Actively Recruiting
9
University of Kansas Cancer Center
Westwood, Kansas, United States, 66103
Actively Recruiting
10
Ochsner Medical Center (OMC) - New Orleans
New Orleans, Louisiana, United States, 70121
Withdrawn
11
University of Maryland Medical Center (UMMC)
Baltimore, Maryland, United States, 21201-1544
Actively Recruiting
12
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Withdrawn
13
Henry Ford Cancer Institute
Detroit, Michigan, United States, 48202-2610
Actively Recruiting
14
Spectrum Health Medical Group (SHMG) - Blood & Marrow Transplant - Adult (BMT)
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
15
University of Rochester Medical Center (URMC)
Rochester, New York, United States, 14642
Actively Recruiting
16
Stony Brook University (SBU) - Cancer Center
Stony Brook, New York, United States, 11794-0001
Actively Recruiting
17
University of Cincinnati Medical Center (University Hospital)
Cincinnati, Ohio, United States, 45267
Actively Recruiting
18
The Ohio State University Comprehensive Cancer Center (OSUCCC)
Cleveland, Ohio, United States, 44106-1716
Actively Recruiting
19
Oregon Health & Science University (OHSU) - Knight Cancer Institute
Portland, Oregon, United States, 97239-3098
Actively Recruiting
20
University of Pennsylvania - Abramson Cancer Center
Philadelphia, Pennsylvania, United States, 19104-4206
Suspended
21
Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States, 75246
Actively Recruiting
22
Hospital El Cruce - Dr. Nestor Kirchner
Buenos Aires, Argentina, B1884LAD
Actively Recruiting
23
Centro de Educacion Medica E Investigacines Clinicas Norberto Quirno CEMIC
Buenos Aires, Argentina
Actively Recruiting
24
Sanatorio Allende (SA) - Nueva Cordoba
Córdoba, Argentina
Actively Recruiting
25
Hospital Italiano La Plata
La Plata, Argentina, 1900
Actively Recruiting
26
CEPON - Centro de Pesquisas Oncologicas
Florianópolis, Santa Catarina, Brazil, 88034-000
Actively Recruiting
27
Hospital Erasto Gaertner
Curicica, Brazil, 81520-060
Actively Recruiting
28
Hospital Alemao Oswaldo Cruz (HAOC)
São Paulo, Brazil, 01327-001
Actively Recruiting
29
Universidade de Sao Paulo (USP) - Hospital das Clinicas da Faculdade de Medicina (HCFMUSP)
São Paulo, Brazil, 05403-000
Actively Recruiting
30
Hospital Israelita Albert Einstein
São Paulo, Brazil, 05652-900
Actively Recruiting
31
Unicamp
São Paulo, Brazil, 13083-878
Actively Recruiting
32
Hospital Amaral Carvalho
São Paulo, Brazil, 17210-080
Actively Recruiting
33
Centre Hospitalier Universitaire (CHU) Angers
Angers, France
Actively Recruiting
34
Centre Hospitalier Regional Universitaire (CHRU) de Lille - Hopital Claude Huriez -
Lille, France
Actively Recruiting
35
Centre Hospitalier Lyon-Sud
Lyon, France, 69495
Actively Recruiting
36
CHU de Nantes - Hôtel Dieu
Nantes, France
Actively Recruiting
37
Hospital Saint Antoine
Paris, France
Actively Recruiting
38
Hôpital Saint Louis
Paris, France
Actively Recruiting
39
Institut Universitaire du Cancer de Toulouse Oncopole
Toulouse, France, 31059
Actively Recruiting
40
Centre de Lutte Contre le Cancer (CLCC) - Institut Gustave-Roussy
Villejuif, France
Actively Recruiting
41
Universitätsklinikum Halle
Halle, Germany
Actively Recruiting
42
Universitaetsklinikum Jena - Klinik fuer Innere Medizin II
Jena, Germany, 07747
Withdrawn
43
University of Leipzig Medical Center
Leipzig, Germany, 04103
Actively Recruiting
44
LMU Klinikum Grosshadern Klinikum der Universitaet Muenchen
Munich, Germany, 81377
Active, Not Recruiting
45
Rambam Health Care Campus
Haifa, Israel
Actively Recruiting
46
Hadassah Medical Center
Jerusalem, Israel
Actively Recruiting
47
The Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Actively Recruiting
48
The Chaim Sheba Medical Center
Tel Litwinsky, Israel
Actively Recruiting
49
Grande Ospedale Metropolitano Bianchi Melacrino Morelli
Reggio Calabria, Calabria, Italy, 89133
Actively Recruiting
50
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Casa Sollievo della Sofferenza (CSS)
San Giovanni Rotondo, Foggia, Italy, 71013
Actively Recruiting
51
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
Alessandria, Italy, 15121
Withdrawn
52
Azienda Sanitaria Locale 13 - Ospedale "C. e G. Mazzoni"- Ascoli Piceno
Ascoli Piceno, Italy, 63100
Actively Recruiting
53
Azienda Sanitaria Localedella provincia di Brindisi -
Brindisi, Italy, 72100
Withdrawn
54
Universita degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC) LAB TMO
Florence, Italy
Actively Recruiting
55
Ospedale Vito Fazzi Lecce
Lecce, Italy, 73100
Actively Recruiting
56
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, Italy
Actively Recruiting
57
Azienda Ospedaliera San Gerardo - Monza
Monza, Italy, 20900
Actively Recruiting
58
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
59
Azienda Ospedaliera Ospedali Riuniti Marche Nord
Pesaro, Italy, 61122
Actively Recruiting
60
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
61
Anjo-kosei Hospital
Anjo-shi, Aichi-ken, Japan, 446-8602
Withdrawn
62
Japanese Red Cross Nagoya Daiichi Hospital (First Hospital)
Nagoya, Aichi-ken, Japan, 466-8550
Actively Recruiting
63
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan, 920-8541
Withdrawn
64
Osaka Metropolitan University Hospital
Osaka, Osaka, Japan, 545-8589
Actively Recruiting
65
Jichi Medical University (JMU) Hospital
Shimotsuke-shi, Tochigi, Japan, 329-0498
Withdrawn
66
Kyushu University Hospital,
Fukuoka, Japan, 812-8582
Actively Recruiting
67
Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital
Hiroshima, Japan, 730-8619
Actively Recruiting
68
Kobe City Medical Center General Hospital
Kobe, Japan, 650-0047
Actively Recruiting
69
Kyoto University Hospital
Kōtoku, Japan, 606-8507
Actively Recruiting
70
Ehime Prefectural Centeral Hospital, Ehime
Matsuyama, Japan, 790-0024
Withdrawn
71
Okayama University Hospital
Okayama, Japan, 700-8558
Actively Recruiting
72
Jichi Medical University Saitama Medical Center
Saitama, Japan, 330-8503
Withdrawn
73
Hokkaido University Hospital
Sapporo, Japan, 060-8648
Actively Recruiting
74
Tokyo Metropolitan Cancer and infection Disese Center Komagome Hospital
Tokyo, Japan
Actively Recruiting
75
Oita University (OU) Hospital
Yufu, Japan, 875593
Withdrawn
76
Sp Zoz Szpital Uniwersytecki W Krakowie
Krakow, Aichi-Ken, Poland, 30-688
Withdrawn
77
Slaski Uniwersytet Medyczny (SUM) w Katowicach - Samodzielny Publiczny Szpital Kliniczny im. Andrzeja Mieleckiego (SPSKM) - Slaskie Centrum Hematologii I Transplantacji Szpiku
Katowice, Silesian Voivodeship, Poland, Silesia
Actively Recruiting
78
Uniwersyteckie Centrum Kliniczne (UCK)
Gdansk, Poland, 80-952
Actively Recruiting
79
Apteka NSSU
Krakow, Poland, 31-501
Withdrawn
80
Centralny Szpital Kliniczny Apteka Szpitalna
Warsaw, Poland, 02-097
Actively Recruiting
81
Institutul Clinic Fundeni
Bucharest, Romania, 022328
Actively Recruiting
82
Spitalul Clinic Coltea
Bucharest, Romania
Withdrawn
83
Institutul Regional de Oncologie Iasi, - Haematology Department
Iași, Romania, 700483
Withdrawn
84
Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)
Barcelona, Spain, 08035
Actively Recruiting
85
Institut Catala d'Oncologia (ICO)
Barcelona, Spain, 8908
Actively Recruiting
86
Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location
Barcelona, Spain, 8916
Withdrawn
87
Hospital Universitario Virgen de las Nieves
Granada, Spain
Actively Recruiting
88
Hospital Universitario de Gran Canaria ""
Las Palmas de Gran Canaria, Spain
Actively Recruiting
89
Hospital De La Princesa
Madrid, Spain
Withdrawn
90
Hospital Universitario 12 de Octubre
Madrid, Spain
Actively Recruiting
91
Hospital Universitario Ramon y Cajal
Madrid, Spain
Actively Recruiting
92
Hospital Clinico Universitario - Universidad de Salamanca
Salamanca, Spain
Actively Recruiting
93
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Actively Recruiting
94
Universitaetsspital Basel
Basel, Switzerland
Actively Recruiting
95
Changhua Christian Hospital
Changhua, Taiwan, 500
Actively Recruiting
96
National Cheng-Kung University Hospital
Tainan, Taiwan, 70403
Withdrawn
97
National Taiwan University Hospital (NTUH)
Taipei, Taiwan, 10002
Actively Recruiting
98
National Taiwan University Cancer Center
Taipei, Taiwan, 106
Actively Recruiting
99
Queen Elizabeth Hospital
Birmingham, United Kingdom, B152TH
Actively Recruiting
100
University Hospital of Wales, Cardiff
Cardiff, United Kingdom, CF14 4XW
Actively Recruiting
101
Queen Elizabeth University Hospital
Glasgow, United Kingdom, G514TF
Actively Recruiting
102
University College Hospital,
London, United Kingdom, NW1 2BU
Actively Recruiting
103
Imperial College, London
London, United Kingdom
Actively Recruiting
104
Manchester Royal Infirmary;Manchester University
Manchester, United Kingdom, M139WL
Actively Recruiting
105
Newcastle Upon Tyne Hospitals Norhtern Center for Cancer Care
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
106
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom, NG5 1PB
Actively Recruiting
107
Oxford University Hospitals
Oxford, United Kingdom
Actively Recruiting
108
Royal Hallamshire Hospital
Sheffield, United Kingdom, S10 2JF
Actively Recruiting
Research Team
M
Malika Souquieres, MSc
CONTACT
J
Jens Hasskarl, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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