Actively Recruiting
Modeling Host-Pathogen Interaction Using Lymphoid Organoids
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-05-14
500
Participants Needed
2
Research Sites
967 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S. aureus interacts with a person s cells to cause infections in the spine. Objective: To learn how S. aureus interacts with cells in the body using tissues from tonsils discarded after standard surgery to remove them. Eligibility: People aged 2 years and older who are scheduled to have their tonsils removed. Design: Researchers will select participants for the study based on review of their existing medical records, including results of blood tests; any imaging scans, including x-rays; and reports about tissue specimens. Participants will answer questionnaires about their health and past infections. They can do this online or on paper. Participants will collect a nasal swab 1 week before their surgery. They will be given a tool that looks like a long cotton swab. They will twirl it around inside their nose. The swab will pick up cells and fluids that will be used for research. After their surgery, the participant s surgeon will save samples of tonsil tissue. The surgeon will send these tissue samples and the nasal swab to researchers at the NIH. These tissues and the swab will be used in studies to help researchers understand how S. aureus interacts with cells in the body. They hope these studies will help them find better ways to treat S. aureus infections.
CONDITIONS
Official Title
Modeling Host-Pathogen Interaction Using Lymphoid Organoids
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 2 years or older
- Scheduled for tonsillectomy as part of clinical care
- Able to provide informed consent or have a parent/guardian provide consent if under 18
- Willing to allow storage and sharing of samples and data for future research
- Willing to allow future genetic testing on biospecimens
You will not qualify if you...
- Having an active infection
- Having active tonsillitis
- Pregnant
- Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications
- Current or past intravenous drug use
- Any condition that may put the participant at undue risk or make them unsuitable for the study according to the investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, United States, 20892
Actively Recruiting
2
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
K
Katherine Le, M.D.
CONTACT
M
Michael Otto, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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