Actively Recruiting
Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Led by University Hospital, Toulouse · Updated on 2026-03-18
20
Participants Needed
2
Research Sites
495 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes. Anomalies in ocular development , often of genetic origin, pose diagnostic and therapeutic challenges. Animal models are limited, so human-induced pluripotent stem cell (hiPSC)-derived optic vesicle containing brain organoids (OVBOs) offer a promising alternative. These pathological OVBOs, created from patients' cells with ocular malformations, allow for the study of underlying molecular mechanisms and testing of therapies.
CONDITIONS
Official Title
Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Affiliated with a social security scheme
- Patients with ocular malformations
- Signed informed consent obtained from the patient and/or their legal representatives
You will not qualify if you...
- Unable to understand the nature and objectives of the study or difficulty communicating with the investigator
- Deprivation of liberty by judicial or administrative decision
- Any pathological or psychological condition deemed incompatible by the investigator for the proper conduct of the study
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
CHU de Clermont-Ferrand - Hôpital d'Estaing
Clermont-Ferrand, France
Actively Recruiting
2
Purpan University Hospital
Toulouse, France, 31059
Actively Recruiting
Research Team
J
Julie Plaisancie, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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