Tracking Recovery Paths and Functional Outcomes in Adults with Severe Acquired Brain Injuries Using Advanced Statistical Modeling

What this Trial Is About

Researchers are studying patients with severe acquired brain injuries ABI, which are a leading cause of death and disability worldwide. The study aims to improve understanding and prediction of recovery progression during intensive rehabilitation care by using new statistical methods that analyze individual clinical changes over time. It also seeks to validate an updated clinical scale called the Early Rehabilitation Barthel Index ERBI to measure functional changes in these patients. Participants are patients admitted to intensive rehabilitation units within three months of their brain injury event. The study collects detailed data on demographics, clinical variables, responsiveness, cognitive function, disability, and care needs. Assessments include tools such as the Coma Recovery Scale, Levels of Cognitive Functioning, Disability Rating Scale, and the ERBI. These evaluations occur at two monthly timepoints up to six months, with monthly assessments continuing if hospitalization extends to 12 months. Throughout the study, researchers measure outcomes using the Glasgow Outcome Scale - Extended GOSE and the ERBI. Data collection involves monitoring clinical variables and medical devices present during rehabilitation. The study duration covers the inpatient rehabilitation period, with up to 12 assessment timepoints to track each patients clinical course and response to intensive care. This approach aims to better describe each patients recovery trajectory and assist future clinical practice.

Modeling Outcome in Patients With Acquired Brain Injuries