Actively Recruiting
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
Led by VA Office of Research and Development · Updated on 2026-02-05
123
Participants Needed
1
Research Sites
227 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investigators will compare how effective working out a lot one week per month with a break of three weeks is to continuously exercising weekly with no breaks in people with mid stage PD. The investigators will look at how fast participants walk per minute, whether they become more physically active, the biochemicals in their blood, and at how stiff their blood vessels are before and after the exercise.
CONDITIONS
Official Title
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Diagnosis of definite Parkinson's disease by a board-certified Movement Disorders Neurologist
- Hoehn and Yahr stages 2, 2.5, or 3 of Parkinson's disease
- Montreal Cognitive Assessment (MoCA) score greater than 17
- Able to walk at least 10 feet with or without an assistive device
- Best corrected/aided vision better than 20/70 in the better eye
- Show clear symptom improvement from antiparkinsonian medications such as levodopa
- Fluent in English and able to comprehend and participate
- Willing to be randomized to a treatment group
You will not qualify if you...
- Untreated major depression or major psychiatric illness
- History of stroke or traumatic brain injury
- Hearing loss with average sensitivity worse than 40 dB at 0.5, 1.0, and 2.0 kHz
- History of alcohol abuse or use of antipsychotic medications
- Planning to be away from the area for more than 1 month during the study
- Taking moderate to high doses of beta-blockers with resting heart rate below 60 beats per minute
- Severe cardiac disease such as advanced congestive heart failure, significant aortic stenosis, history of cardiac arrest, use of cardiac defibrillator, or uncontrolled angina
- Other significant health conditions that impair exercise participation, including renal failure on hemodialysis or excessive alcohol use exceeding 14 drinks per week
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033-4004
Actively Recruiting
Research Team
M
Madeleine E Hackney, PhD
CONTACT
J
Joe R Nocera, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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