Actively Recruiting
Modern Technologies for Individual Risk Stratification in Infant Lower Respiratory Tract Infections
Led by Helse Møre og Romsdal HF · Updated on 2026-02-02
200
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Helse Møre og Romsdal HF
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Lower respiratory tract infections (LRTIs) are a leading cause of illness and hospitalization in infants worldwide, especially in low-income areas. In Norway, bronchiolitis, a common viral LRTI affecting small airways, causes breathing and feeding difficulties and can increase the risk of chronic lung disease such as asthma. This observational study aims to improve diagnosis and treatment by using lung ultrasonography (LUS) and tidal breathing flow volume loops (TBFVL) to better assess disease severity and predict long-term outcomes in infants with LRTIs. The study uses modern diagnostic tools including bedside lung ultrasound and tidal flow volume loops to objectively evaluate airway obstruction and lung involvement in hospitalized infants under two years old with LRTIs. Researchers will explore how these tools correlate with clinical symptoms, length of hospital stay, respiratory support needs, and intensive care admissions. The project also includes developing AI-driven scoring for ultrasound images and following patients for 12 months to assess post-infection symptoms and lung function. Participants will undergo lung ultrasound and tidal flow volume loop tests during hospitalization and follow-up visits. Researchers will monitor symptom duration, hospital readmissions, and lung function over a year. The study measures include number of readmissions, hospital stay length, and symptom duration after discharge. This research aims to identify infants at high risk for chronic lung disease to tailor treatments and improve long-term care, while providing caregivers with clearer information about symptom progression and risks.
CONDITIONS
Brief Title
Modern Technologies in Lower Respiratory Tract Infections in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of lower respiratory tract infection
- Presence of tachypnea and/or wheezing
- Signs of retractions
- Respiratory difficulties
- Children younger than 24 months old
You will not qualify if you...
- Severe congenital heart disease (except ASD, small VSD, PDA)
- Cystic fibrosis or primary ciliary dyskinesia
- Neuromuscular diseases or other conditions reducing airway clearance
- Severe malacia diagnosed by bronchoscopy at baseline
- Foreign body inhalation
- Pneumothorax
- Pleural effusion requiring invasive intervention
- Bronchopulmonary dysplasia or gestational age less than 32 weeks
- Caretaker unable to communicate in Norwegian or English
- Weight less than 3 kg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 3 days
Participants undergo lung ultrasound and tidal-flow volume loops to assess their lower respiratory tract infections while hospitalized.
1 to 2 visits during hospitalization
Duration - Up to 12 months
Participants are followed for up to 12 months after baseline to monitor readmissions, symptom duration, and respiratory outcomes.
Follow-up assessments over 12 months
Trial Site Locations
Total: 2 locations
1
Aalesund Hospital
Ålesund, Møre og Romsdal, Norway, 6017
Actively Recruiting
2
St. Olavs Hospital HF
Trondheim, Sør-Trøndelag, Norway, 7030
Not Yet Recruiting
Research Team
H
Hans Kristian S Ipsen, medical doctor
K
Kari Risnes, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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