Using Transcranial Direct Current Stimulation tDCS to Reduce Craving and Improve Control in Alcohol Use Disorder Comparing Different Brain Stimulation Methods as Add-On Treatments During Detox

What this Trial Is About

Researchers are evaluating transcranial direct current stimulation tDCS as an add-on treatment to reduce cognitive deficits and substance craving in individuals with substance use disorders, focusing on alcohol use disorder. The study aims to identify the best electrode placement and current direction for tDCS to improve inhibitory control and reduce craving, which could lead to longer abstinence and less substance use after relapse. This is important as previous findings on tDCS effects in this area have been conflicting. Participants receive one of several interventions alongside standard detoxification treatment three different active tDCS conditions targeting specific brain areas, a sham placebo tDCS, computerized inhibition training, or no additional intervention. tDCS sessions last 20 minutes each and are given on five consecutive days, with electrodes placed precisely using an EEG cap. Inhibition training uses a computerized GoNo-Go task with alcohol-related images. Participants undergo psychometric, neuropsychological, and EEG assessments before, during, and after the interventions, including tasks measuring inhibitory control. Follow-up occurs at 4, 8, 12, and 24 weeks post-treatment to assess craving, relapse, and alcohol use. EEG and behavioral tests are repeated to monitor changes. The total study duration includes intervention days and several follow-up assessments to track long-term outcomes.

Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder