Actively Recruiting
Phase 1 Study of TAG72-Targeting CAR T Cell Therapy for Women With Advanced Platinum-Resistant Epithelial Ovarian Cancer
Led by City of Hope Medical Center · Updated on 2026-07-01
33
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the safety, side effects, and best dose of TAG72-chimeric antigen receptor CAR T cells in patients with epithelial ovarian cancer that does not respond to platinum therapy, known as platinum-resistant epithelial ovarian cancer. This phase I trial aims to find the maximum tolerated dose and recommended dose for future studies. The study also looks at how long these modified immune cells last in the body, their effectiveness against the cancer, and measures related to immune response and survival. Participants receive chemotherapy drugs fludarabine and cyclophosphamide intravenously for three days before receiving a single dose of TAG72-CAR T cells administered directly into the peritoneal cavity on day 0. This dose-escalation study monitors patients closely after treatment, with follow-up visits scheduled frequently in the first three months and continuing for up to 15 years to assess long-term effects and outcomes. During the study, participants undergo various assessments including blood and tissue tests to monitor the presence and activity of the CAR T cells, tumor response, and immune system changes. Safety is carefully tracked by recording any side effects or toxicities up to one year post-treatment. The research team also evaluates survival and progression-free survival rates, cytokine levels, and genetic markers. Participants are followed for an extended period to gather comprehensive data on the treatments impact and safety.
CONDITIONS
Brief Title
Modified Immune Cells (TAG72-CAR T Cells) for the Treatment of Patients With Platinum Resistant Epithelial Ovarian Cancer
Research Team
L
Lorna Rodriguez
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